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Research has shown that, depending on the method used to detect the virus, anywhere from 20%-80% of people who have had mononucleosis and have recovered will continue to secrete the EBV in their saliva for years due to periodic "reactivations" of the viral infection.

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It typically takes between four to eight weeks for people become symptomatic after the initial Epstein-Barr virus infection.Most people have been exposed to the virus as children, and as a result of the exposure, they have developed immunity to the virus.It is of note that most people who are exposed to the EBV don't ever develop mononucleosis.It is currently believed that these healthy people, who nevertheless secrete EBV particles, are the primary reservoir for transmission of EBV among humans.Therefore, it can be difficult to precisely determine how long the infection may be contagious.By the time most people reach adulthood, antibodies against EBV can be detected in their blood. S., up to 95% of adults 35-40 years of age have antibodies directed against EBV.

This means that most people, sometime in their lives, have been infected with EBV.

Early in the course of disease (over the first few days of illness), a temporary swelling (edema) of both upper eyelids may appear.

The diagnosis of mono is suspected by the doctor based on the above symptoms and signs.

The term infectious mononucleosis was first used in 1920 when an increased number of lymphocytes were found in the blood of a group of college students who had fever and symptoms of the condition.

The EBV that causes mono is found throughout the world.

The incubation period for mono, meaning the time from the initial viral infection until the appearance of clinical symptoms, is between four and eight weeks.