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Red Cross Plasma Services provides plasma products that are reliable, cost-effective and as safe as possible.In February 1999, ARC completed its "Transformation", a $287 million program that: re-engineered Red Cross Blood Services' processing, testing and distribution system; and established a new management structure.

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Barton organized a meeting on May 12 of that year at the home of Senator Omar D. Clara Barton (1821–1912) founded the American chapter after learning of the Red Cross in Geneva, Switzerland.Leukocytes in stored blood products can have a variety of biological effects, including depression of immune function, which can result in organ failure and death.Because whole blood is rarely used for transfusion and not kept in routine inventory, leukoreduced red blood supplies are critical.The first chapters opened in upstate New York, where she had connections.Barton led one of the group's first major relief efforts, a response to the September 4–6, 1881 Great Fire of 1881 (Thumb Fire) in the Thumb region of Michigan. The next major disaster was the Johnstown Flood, which occurred on May 31, 1889.is a humanitarian organization that provides emergency assistance, disaster relief and education in the United States. In 1869, she went to Europe and became involved in the work of the International Red Cross during the Franco-Prussian War.

It is the designated US affiliate of the International Federation of Red Cross and Red Crescent Societies. She determined to bring the organization to America.

New leader Mabel Thorp Boardman constantly consulted with senior government officials, military officers, social workers and financiers. They imposed an ethos of "managerialism", transforming the agency from Barton's cult of personality to an "organizational humanitarianism" ready for expansion.

ARC is a nationwide network of more than 650 chapters and 36 blood service regions.

For more than 50 years, ARC provided allograft tissue for transplant through sales in its Tissue Services Program.

It cared for thousands of donor families who gave the gift of tissue donation and sold donated tissue to more than 1 million transplant recipients in need of this life saving or life-enhancing gift of tissue.

As of 2011, ARC was no longer in the Plasma Services industry. blood bank to implement a Nucleic acid testing (NAT) study.